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Literature summary for 2.4.1.B62 extracted from
- Glucosylation of Rho proteins by Clostridium difficile toxin B (1995), Nature, 375, 500-503.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridioides difficile | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucose + RhoA | - |
Clostridioides difficile | UDP + D-glucosyl-RhoA | toxin B catalyses the incorporation of up to one mole of glucose per mole of RhoA at the amino acid threonine at position 37. UDP-glucose selectively serves as cosubstrate for the monoglucosylation reaction | ? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | microinjection of RhoA previously glucosylated by toxin B into monolayer cells causes disaggregation of actin filaments, indicating a dominant-negative activity of glucosylated RhoA | Clostridioides difficile |
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