Literature summary for 2.4.1.B62 extracted from

Ko, S.H.; Jeon, J.I.; Kim, H.; Kim, Y.J.; Youn, J.; Kim, J.M.
Mitogen-activated protein kinase/IkappaB kinase/NF-kappaB-dependent and AP-1-independent CX3CL1 expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A (2014), J. Mol. Med., 92, 411-427.

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Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-

General Information

General Information	Comment	Organism
physiological function	stimulation of murine intestinal epithelial cells with toxin A results in the upregulation of chemokine CX3CL1. Expression of CX3CL1 is dependent on nuclear factor kappaB and I?appaB kinase activation. A pathway, including p38 mitogen-activated protein kinase, IkappaB kinase , and nuclear factor kappaB activation, is required for CX3CL1 induction in intestinal epithelial cells exposed to toxin A and may regulate the development of intestinal inflammation induced by infection with toxigenic Peptoclostridium difficile	Clostridioides difficile

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Release 2023.1 (January 2023)