Literature summary for 2.4.1.B62 extracted from

Blake, J.; Mitsikosta, F.; Metcalfe, M.
Immunological detection and cytotoxic properties of toxins from toxin A-positive, toxin B-positive Clostridium difficile variants (2004), J. Med. Microbiol., 53, 197-205.

Search for more literature for 2.4.1.B62

Application

Application	Comment	Organism
analysis	development of a rapid and simple method for toxin A removal from culture filtrates	Clostridioides difficile
medicine	toxin A-positive, toxin B-positive strains representing 12 variant toxinotypes all express considerably lower levels of toxin A and are less cytotoxic in vitro than non-variant strain VPI 10463. Truncated forms of toxin occur in toxinotype VI and VII strains and these toxins are differentiated from each other and from toxin A of the non-variant strain. Toxin A-positive, toxin B-positive strains of toxinotypes IX, XIV and XV are able to exhibit an alternative Clostridium sordellii-like cytopathic effect on Vero cells, characterized by marked cell clumping. The abnormal cytotoxicity observed for these strains is due to an altered toxin B	Clostridioides difficile

Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-

General Information

General Information	Comment	Organism
physiological function	toxin A-positive, toxin B-positive strains representing 12 variant toxinotypes all express considerably lower levels of toxin A and are less cytotoxic in vitro than non-variant strain VPI 10463. Truncated forms of toxin occur in toxinotype VI and VII strains and these toxins are differentiated from each other and from toxin A of the non-variant strain. Toxin A-positive, toxin B-positive strains of toxinotypes IX, XIV and XV are able to exhibit an alternative Clostridium sordellii-like cytopathic effect on Vero cells, characterized by marked cell clumping. The abnormal cytotoxicity observed for these strains is due to an altered toxin B	Clostridioides difficile

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Release 2023.1 (January 2023)