Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
x * 220000, x * 43000, SDS-PAGE | Clostridioides difficile |
105000 | - |
and 220000, PAGE of toxin B | Clostridioides difficile |
220000 | - |
and 105000, PAGE. The 220000 Da subunit of toxin B from strain 8864 migrates slightly faster than the subunit from strain 10463 | Clostridioides difficile |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridioides difficile | - |
strain does not produce toxin A | - |
Clostridioides difficile 8864 | - |
strain does not produce toxin A | - |
Purification (Comment) | Organism |
---|---|
purification of toxin B from strain 8864 that does not produce toxin A | Clostridioides difficile |
Subunits | Comment | Organism |
---|---|---|
multimer | x * 220000, x * 43000, SDS-PAGE | Clostridioides difficile |
General Information | Comment | Organism |
---|---|---|
physiological function | strain 8864 which does not produce toxin A produces a modified toxin B. After treatment of fibroblasts with toxin B from strain 10463, which produces both toxin A and toxin B, cells become rounded and highly arborised, giving the characteristic actinomorphic appearance. With the toxin B from strain 8864, no arborisation of cells occurrs but there is rounding and significant detachment | Clostridioides difficile |