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Literature summary for 2.4.1.B62 extracted from

  • Castagliuolo, I.; Sardina, M.; Brun, P.; DeRos, C.; Mastrotto, C.; Lovato, L.; Palu, G.
    Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant (2004), Infect. Immun., 72, 2827-2836.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information a nontoxigenic peptide corresponding to amino acids 2394 to 2706 of toxin A acts a a mucosal adjuvant. The adjuvant effect following oral, but not intranasal, immunization is dose dependent. Splenocytes of immunized mice challenged in vitro with keyhole limpet hemocyanin indicate the induction of a mixed Th1/Th2-type immune response, with prevalence of the Th1 branch Clostridioides difficile

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
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Clostridioides difficile VPI 10463
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