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Literature summary for 2.4.1.92 extracted from

  • Dicesare, J.L.; Dain, J.A.
    The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain (1971), Biochim. Biophys. Acta, 231, 385-393.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Detergents CF-54, Tween 80 Rattus norvegicus
Triton CF-54
-
Rattus norvegicus
Tween 80
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0166
-
GM3
-
Rattus norvegicus
0.057
-
UDP-N-acetyl-D-galactosamine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ not Rattus norvegicus
Mg2+ not Rattus norvegicus
Mn2+
-
Rattus norvegicus
additional information no activation by K+, Al3+ Rattus norvegicus
Ni2+ not Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide Rattus norvegicus involved in biosynthesis of gangliosides in brain UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GM3(O-acetyl-(N-glycolyl)neuraminic acid) + UDP-N-acetyl-D-galactosamine less effective substrate Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-GM3(O-acetyl-(N-glycolyl)neuraminic acid)
-
?
additional information poor substrate: GM2-, GM1-, GD1b- and GT1-gangliosides and various ceramides Rattus norvegicus ?
-
?
additional information no substrate: N-acetylglucosamine Rattus norvegicus ?
-
?
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide less effective: GM3(O-acetyl-(N-glycolyl)neuraminic acid) Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM3(N-acetylneuraminic acid), best substrate Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide involved in biosynthesis of gangliosides in brain Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
?
UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside not as effective as GM3(N-acetylneuraminic acid) Rattus norvegicus UDP + GM2(N-glycolylneuraminic acid)-ganglioside
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.2
-
Rattus norvegicus