Literature summary for 2.4.1.90 extracted from

Chatterjee, S.B.; Hou, J.; Bandaru, V.V.R.; Pezhouh, M.K.; Syed Rifat Mannan, A.A.; Sharma, R.
Lactosylceramide synthase beta-1,4-GalT-V A novel target for the diagnosis and therapy of human colorectal cancer (2019), Biochem. Biophys. Res. Commun., 508, 380-386 .

Search for more literature for 2.4.1.90

Application

Application	Comment	Organism
medicine	the enzyme serves as a diagnostic and therapeutic biomarker for the progression of human colorectal cancer	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol	potent inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine	Homo sapiens	-	UDP + N-acetyllactosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine	-	Homo sapiens	UDP + N-acetyllactosamine	-	?

Synonyms

Synonyms	Comment	Organism
B4GalT5	-	Homo sapiens
beta-1,4-galactosyltransferase-V	-	Homo sapiens
beta-1,4-GalT-V	-	Homo sapiens
lactosylceramide synthase	-	Homo sapiens
UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme gene/protein expression is specifically increased in human colorectal cancer compared to visibly normal tissue	up

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Release 2023.1 (January 2023)