Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.80 extracted from

  • Wegner, M.S.; Schoemel, N.; Gruber, L.; Oertel, S.B.; Kjellberg, M.A.; Mattjus, P.; Kurz, J.; Trautmann, S.; Peng, B.; Wegner, M.; Kaulich, M.; Ahrends, R.; Geisslinger, G.; Groesch, S.
    UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018), Cell. Mol. Life Sci., 75, 3393-3410 .
    View publication on PubMed
Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment) Organism
expression in MCF-7 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16739
-
-

Synonyms

Synonyms Comment Organism
Ugcg
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function UGCG overexpression in breast cancer cells leads to morphological changes, which enhance proliferation and doxorubicin resistance. These effects seem to be mediated by an altered composition of glycosphingolipid-enriched microdomains, especially an accumulation of globotriaosylceramide and glucosylceramide, which leads to an activation of Akt and ERK1/2. The induction of the Akt and ERK1/2 signaling pathway results in an increased gene expression of multidrug resistance protein 1 and anti-apoptotic genes and a decrease of pro-apoptotic gene expression Homo sapiens