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Literature summary for 2.4.1.80 extracted from

  • Crespo, P.M.; Silvestre, D.C.; Gil, G.A.; Maccioni, H.J.; Daniotti, J.L.; Caputto, B.L.
    c-Fos activates glucosylceramide synthase and glycolipid synthesis in PC12 cells (2008), J. Biol. Chem., 283, 31163-31171.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
c-Fos activity of glucosylceramide synthase is around 5fold higher in presence of high c-Fos levels, induced by nerve growth factor NGF, addition of c-Fos mRNA ASO, which specifically blocks c-Fos expression abolished the induction of glucosylceramide synthase by NGF Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in PC12 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0069
-
UDP-glucose in absence of c-Fos Homo sapiens
0.0079
-
UDP-glucose in presence of c-Fos Homo sapiens
0.013
-
N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine in absence of c-Fos Homo sapiens
0.02
-
N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine in presence of c-Fos Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + N-6-[(7-nitrobenzo-2-oxa-1,3-diazol-4-yl)amino]hexanoyl-4-D-erythro-sphingosine
-
Homo sapiens UDP + N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine
-
?

Synonyms

Synonyms Comment Organism
GlcCerS
-
Homo sapiens
glucosylceramide synthase
-
Homo sapiens