Application | Comment | Organism |
---|---|---|
medicine | it is shown that pharmacological lowering of glycosphingolipids, without significant reduction of ceramide, dramatically reverses insulin resistance in in vitro and in vivo models and may present a novel approach to the therapy of type 2 diabetes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(5'-adamantan-1'-yl-methoxy)-pentyl-1-deoxynojirimycin | highly specific small molecule inhibitor of glucosylceramide synthase. When administered to mice and rats, it significantly reduces glycosphingolipid but not ceramide concentrations in various tissues. Treatment of ob/ob mice with the inhibitor normalizes their elevated tissue glucosylceramide levels, markedly lowers circulating glucose levels, improves oral glucose tolerance, reduced A1C, and improves insulin sensitivity in muscle and liver | Mus musculus | |
N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynojirimycin | pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | Mus musculus | the enzyme catalyzes a necessary step in the conversion of ceramide to glycosphingolipids | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
NIH-3T3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | the enzyme catalyzes a necessary step in the conversion of ceramide to glycosphingolipids | Mus musculus | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Mus musculus |
glucosylceramide synthase | - |
Mus musculus |