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Literature summary for 2.4.1.80 extracted from

  • Couto, A.S.; Caffaro, C.; Uhrig, M.L.; Kimura, E.; Peres, V.J.; Merino, E.F.; Katzin, A.M.; Nishioka, M.; Nonami, H.; Erra-Balsells, R.
    Glycosphingolipids in Plasmodium falciparum. Presence of an active glucosylceramide synthase (2004), Eur. J. Biochem., 271, 2204-2214.
    View publication on PubMed
Search for more literature for 2.4.1.80

Application

Application Comment Organism
pharmacology enzyme might be an attractive target for malarial chemotherapy Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
D,L-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol enzyme inhibition in vitro and in vivo, in the latter case the compound also inhibits growth of the parasite Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum lipid profile of the parasite at different developmental stages, overview ?
-
 ?
UDP-glucose + N-acylsphingosine Plasmodium falciparum key step in biosynthesis of glycosphingolipids UDP + D-glucosyl-N-acylsphingosine
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information intraerythrocytic stages of the parasite Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lipid profile of the parasite at different developmental stages, overview Plasmodium falciparum ?
-
 ?
UDP-glucose + dihydroceramide mono-, tri-, and tetrahexosylceramides, the parasite enzyme is only active on the saturated substrate Plasmodium falciparum UDP + D-glucosyl-dihydroceramide product analysis ?
UDP-glucose + N-acylsphingosine
-
 Plasmodium falciparum UDP + D-glucosyl-N-acylsphingosine
-
 ?
UDP-glucose + N-acylsphingosine key step in biosynthesis of glycosphingolipids Plasmodium falciparum UDP + D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

Synonyms Comment Organism
GCS
-
 Plasmodium falciparum
glucosylceramide synthase
-
 Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Plasmodium falciparum