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Literature summary for 2.4.1.80 extracted from

  • Hillig, I.; Warnecke, D.; Heinz, E.
    An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms (2005), Biosci. Biotechnol. Biochem., 69, 1782-1785.
    View publication on PubMed
Search for more literature for 2.4.1.80

Cloned(Commentary)

Cloned (Comment) Organism
expression in an enzyme-deficient strain of Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(D-threo)-1-(3',4'-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol the inhibitor is abolutely specific for the recombinant human enzyme and does not affect recombinant non-human enzymes from Gossypium arboreum, Caenorhabditis elegans, Aspergillus nidulans, Candida albicans, Pichia pastoris, Ustilago maydis, or Agrobacterium tumefaciens Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + ceramide Homo sapiens
-
 UDP + glucosylceramide glucosylceramide is a precursor for synthesis of a multitude of higher sphingolipids ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + ceramide
-
 Homo sapiens UDP + glucosylceramide
-
 ?
UDP-glucose + ceramide
-
 Homo sapiens UDP + glucosylceramide glucosylceramide is a precursor for synthesis of a multitude of higher sphingolipids ?

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens