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Literature summary for 2.4.1.80 extracted from

  • Hayashi, Y.; Horibata, Y.; Sakaguchi, K.; Okino, N.; Ito, M.
    A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates (2005), Anal. Biochem., 345, 181-186.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + ceramide Cricetulus griseus key enzyme in the synthesis of major glycosphingolipids in vertebrates UDP + glucosylceramide glucosylceramide is the core structure of major glycosphingolipids ?
UDP-glucose + ceramide Danio rerio key enzyme in the synthesis of major glycosphingolipids in vertebrates UDP + glucosylceramide glucosylceramide is the core structure of major glycosphingolipids ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Danio rerio
-
zebrafish
-

Source Tissue

Source Tissue Comment Organism Textmining
CHOP cell ovary cells expressing the LT antigen Cricetulus griseus
-
embryo
-
Danio rerio
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay method development Cricetulus griseus
additional information
-
assay method development Danio rerio

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 6-([(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]caproyl)sphingosine synthetic fluorescent substrate in liposomes for assay method development Cricetulus griseus UDP + N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine
-
?
UDP-glucose + 6-([(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]caproyl)sphingosine synthetic fluorescent substrate in liposomes for assay method development Danio rerio UDP + N-(6-((4-nitrobenz-2-oxa-1,3-diazol-7-yl)amino)caproyl)-O1-D-glucosyl-sphingosine
-
?
UDP-glucose + ceramide
-
Cricetulus griseus UDP + glucosylceramide
-
?
UDP-glucose + ceramide
-
Danio rerio UDP + glucosylceramide
-
?
UDP-glucose + ceramide key enzyme in the synthesis of major glycosphingolipids in vertebrates Cricetulus griseus UDP + glucosylceramide glucosylceramide is the core structure of major glycosphingolipids ?
UDP-glucose + ceramide key enzyme in the synthesis of major glycosphingolipids in vertebrates Danio rerio UDP + glucosylceramide glucosylceramide is the core structure of major glycosphingolipids ?

Synonyms

Synonyms Comment Organism
GlcT
-
Cricetulus griseus
GlcT
-
Danio rerio
glucosylceramide synthase
-
Cricetulus griseus
glucosylceramide synthase
-
Danio rerio