Literature summary for 2.4.1.68 extracted from

Garcia-Garcia, A.; Ceballos-Laita, L.; Serna, S.; Artschwager, R.; Reichardt, N.C.; Corzana, F.; Hurtado-Guerrero, R.
Structural basis for substrate specificity and catalysis of alpha-1,6-fucosyltransferase (2020), Nat. Commun., 11, 973 .

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of FUT8 complexed with GDP and a biantennary complex N-glycan (G0). FUT8 follows an SN2 mechanism and deploys a series of loops and an alpha-helix which all contribute in forming the binding site. An exosite, formed by one of these loops and an SH3 domain, is responsible for the recognition of branched sugars, making contacts specifically to the alpha-1,3 arm GlcNAc, required for catalysis	Homo sapiens

Crystallization (Comment)

Organism

structure of FUT8 complexed with GDP and a biantennary complex N-glycan (G0). FUT8 follows an SN2 mechanism and deploys a series of loops and an alpha-helix which all contribute in forming the binding site. An exosite, formed by one of these loops and an SH3 domain, is responsible for the recognition of branched sugars, making contacts specifically to the alpha-1,3 arm GlcNAc, required for catalysis

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYC5	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)