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Literature summary for 2.4.1.68 extracted from
- Mammalian alpha-1,6-fucosyltransferase (FUT8) is the sole enzyme responsible for the N-acetylglucosaminyltransferase I-independent core fucosylation of high-mannose N-glycans (2016), J. Biol. Chem., 291, 11064-11071 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BYC5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293S cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP-beta-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-erythropoietin | - |
Homo sapiens | GDP + L-fucose alpha-1,6 bound to the erythropoitin-linked N-acetylglucosamine of Gal-N-acetylglucosaminyl-Man5 + GDP | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | FUT8 is the sole enzyme responsible for the N-acetylglucosaminyltransferase GnT I-independent core fucosylation pathway. In a a stable HEK-293S GnT I-/- cell line with either knockdown of FUT8, the erythropoietin produced shows the pure Man5GlcNAc2 glycoform, whereas that produced from the FUT8-overexpressing cell line is fully core-fucosylated oligomannose glycan (Man5GlcNAc2Fuc) | Homo sapiens |
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Release 2023.1 (January 2023)
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