Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a candidate for the earliest marker of megakaryocyte-commitment in cultured hematopoietic stem cells. Such a marker should allow an earlier detection and earlier transplantation of patients own, ex vivo expanded, megakaryocyte progenitors | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa (CD41a) which is present in megakaryocytes and platelets | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | heavy load of 6FucT | Homo sapiens | - |
hematopoietic stem cell | CD34+ cell, activity of 6FucT increases ahead of, and thereafter concomitantly with, cells expressing the CD41a antigen. When the CD41a+ subpopulation of cells is immunoselected (using anti-CD61 i.e. anti GpIIIa antibodies), its 6FucT activity increases proportionally to the yield of DC61+ cells | Homo sapiens | - |
megakaryocyte | heavy load of 6FucT | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa (CD41a) which is present in megakaryocytes and platelets | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6FucT | - |
Homo sapiens |
alpha1,6-fucosyltransferase | - |
Homo sapiens |