Application | Comment | Organism |
---|---|---|
medicine | serum alpha1-6-fucosylated alpha-fetoprotein is employed for an early diagnosis of patients with hepatoma and hepatic disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Sus scrofa |
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene transfection to human hepatoma and mice mutants, overexpression and effects on tumour growth | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | - |
Homo sapiens | |
Co2+ | - |
Homo sapiens | |
Cu2+ | - |
Homo sapiens | |
Cu2+ | - |
Sus scrofa | |
additional information | - |
Homo sapiens | |
additional information | - |
Sus scrofa | |
Ni2+ | - |
Homo sapiens | |
Ni2+ | - |
Sus scrofa | |
Zn2+ | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0042 | - |
GDP-L-fucose | - |
Homo sapiens | |
0.025 | - |
N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine) | - |
Sus scrofa | |
0.028 | - |
GDP-L-fucose | - |
Homo sapiens | |
0.029 | - |
asialo-agalacto-transferrin-glycopeptide | - |
Homo sapiens | |
0.046 | - |
GDP-L-fucose | - |
Sus scrofa | |
0.066 | - |
asialo-agalacto-transferrin-glycopeptide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | - |
Homo sapiens | - |
- |
additional information | no mRNA expression in pancreas and liver | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation | Homo sapiens | |
Mg2+ | activation | Homo sapiens | |
Mg2+ | fibroblast, required | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
amino acid sequence, alignment and comparison | Sus scrofa |
additional information | - |
amino acid sequence, alignment and comparison | Homo sapiens |
additional information | - |
amino acid sequence alignment and comparison of conserved regions, consensus peptide motif | Homo sapiens |
additional information | - |
amino acid sequence alignment and comparison of conserved regions, consensus peptide motif | Sus scrofa |
34000 | - |
x * 34000 + x * 39000 | Homo sapiens |
39000 | - |
x * 34000 + x * 39000 | Homo sapiens |
58000 | - |
1 * 58000, SDS-PAGE | Homo sapiens |
58000 | - |
x * 58000, SDS-PAGE | Sus scrofa |
60000 | - |
x * 60000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9BYC5 | - |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Sus scrofa | P79282 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
no glycoprotein | no N-glycosylation sites in predicted amino acid sequence | Sus scrofa |
no glycoprotein | no N-glycosylation sites in predicted amino acid sequence | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] | type II transmembrane protein | Homo sapiens | |
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] | type II transmembrane protein | Sus scrofa | |
GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] | fucosyltransferase gene superfamily | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | thrombin-activated neutrophils release cathepsin G and elastase during coagulation of blood, which promotes the degranulation of platelets and hence the secretion of alpha-6-fucosyltransferase | Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Sus scrofa | - |
hepatoma cell | expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview | Homo sapiens | - |
hepatoma cell | expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview | Rattus norvegicus | - |
intestine | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | enzyme is expressed in hepatoma tissues and their surrounding tissues with chronic disease, but not in normal liver | Homo sapiens | - |
lung cancer cell line | - |
Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
serum | - |
Rattus norvegicus | - |
skin fibroblast | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Sus scrofa |
additional information | - |
activity in hepatic disease | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-L-fucose + asialo-agalactotransferrin glycopeptide | biantennary to tetraantennary substrates, with the triantennary substrate showing the highest activity | Homo sapiens | GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of the asialo-agalactotransferrin glycopeptide | - |
? | |
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine | - |
Homo sapiens | GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine | - |
? | |
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine | - |
Rattus norvegicus | GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine | - |
? | |
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine | - |
Sus scrofa | GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine | - |
? | |
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine) | - |
Sus scrofa | GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine) | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000, SDS-PAGE | Homo sapiens |
? | x * 58000, SDS-PAGE | Sus scrofa |
? | x * 34000 + x * 39000 | Homo sapiens |
monomer | 1 * 58000, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | 37 | - |
Sus scrofa |
30 | 37 | - |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
4 | 10 | - |
Sus scrofa |
4 | 10 | - |
Homo sapiens |