Cloned (Comment) | Organism |
---|---|
LH3-V5/His fusion protein is expressed in HEK-293 cells | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
96000 | - |
x * 96000, LH3-V5/His fusion protein, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
LH3-V5/His fusion protein is purified using nickel-nitrilotriacetic acid-agarose resin column chromatography | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | - |
Mus musculus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 96000, LH3-V5/His fusion protein, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
LH3 | - |
Mus musculus |
LH3 | - |
Homo sapiens |
lysyl hydroxylase 3 | - |
Homo sapiens |
lysyl hydroxylase 3 | a multifunctional collagen-modifying enzyme possessing lysyl hydroxylase, hydroxylysine galactosyltransferase, and galactosylhydroxylysine-glucosyltransferase activities | Mus musculus |
PLOD3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | an impairment of lysyl hydroxylase 3 function significantly affects type I collagen fibrillogenesis | Mus musculus |
malfunction | lysyl hydroxylase 3-mediated glucosylation occurs at specific sites in collagen, including cross-linking sites, and suppression of this modification results in defective collagen and mineralization | Homo sapiens |
metabolism | lysyl hydroxylase 3 functions as glucosyltransferase in type I collagen | Homo sapiens |
physiological function | the lysyl hydroxylase 3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization | Homo sapiens |
physiological function | the major function of lysyl hydroxylase 3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen | Mus musculus |