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Literature summary for 2.4.1.65 extracted from

  • Brazil, J.C.; Liu, R.; Sumagin, R.; Kolegraff, K.N.; Nusrat, A.; Cummings, R.D.; Parkos, C.A.; Louis, N.A.
    alpha3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration (2013), J. Immunol., 191, 4804-4817.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.65

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R Homo sapiens isoform Fut3 predominantly exhibits alpha1-4 fucosyltransferase activity GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
intestinal epithelial cell
-
 Homo sapiens
-
SKCO-15 cell
-
 Homo sapiens
-
T-84 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R isoform Fut3 predominantly exhibits alpha1-4 fucosyltransferase activity Homo sapiens GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R
-
 ?

Synonyms

Synonyms Comment Organism
alpha3/4 fucosyltransferase 3
-
 Homo sapiens
FUT3
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform Fut3 expression drives sialyl Lewis A synthesis in V6 variant of CD44-expressing cells Homo sapiens