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Literature summary for 2.4.1.65 extracted from

  • Bengtson, P.; Lundblad, A.; Larson, G.; Pahlsson, P.
    Polymorphonuclear leukocytes from individuals carrying the G329A mutation in the alpha 1,3-fucosyltransferase VII gene (FUT7) roll on E- and P-selectins (2002), J. Immunol., 169, 3940-3946.
    View publication on PubMed
Search for more literature for 2.4.1.65

Protein Variants

Protein Variants Comment Organism
R110Q naturally occurring missense mutation in the FUT7 gene, the mutation abolishes FUT7 enzyme activity and synthesis of E-selectin binding ligands on leukocytes, and increases the expression of FUT4, the mutant shows unaltered synthesis of P-selectin binding ligand, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in the biosynthesis of the sialyl Lewis x, i.e. Lex, epitope on leukocytes, which has been identified as an important component of leukocyte ligands for E- and P-selectin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
additional information determination of expression levels in wild-type and R110Q mutant leukocytes Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the biosynthesis of the sialyl Lewis x, i.e. Lex, epitope on leukocytes, which has been identified as an important component of leukocyte ligands for E- and P-selectin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha 1,3-fucosyltransferase VII
-
 Homo sapiens
FUT7
-
 Homo sapiens