Literature summary for 2.4.1.65 extracted from

Guo, P.; Zhang, Y.; Zhang, X.Y.; Chen, H.L.; Wang, H.; Narimatsu, H.
Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells (2003), J. Exp. Clin. Cancer Res., 22, 135-139.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GDP-L-fucose + Lewis antigen	Homo sapiens	on the cell surface of hepatocarcinoma cells H7721	GDP + fucosylated Lewis antigen	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	at least 6 alpha1,3FucT enzymes III-VII and IX, alpha1,3/1,4FucT III is a bifunctional enzyme	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H-7721 cell	hepatocarcinoma cell, expression levels of alpha1,3FucT enzyme types in descending order: alphaFucT IV, III, VI, VI, VII, and IX	Homo sapiens	-
hepatoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-L-fucose + Lewis antigen	on the cell surface of hepatocarcinoma cells H7721	Homo sapiens	GDP + fucosylated Lewis antigen	-	?
GDP-L-fucose + Lewis antigen	the enzyme, especially subtype FucT VI, is responsible for alpha-1,3-fucosylation in the synthesis of Lewis antigens Lex, SLex, and SDLex on the cell surface consist of sialylated or nonsialylated N-acetyllactosamine located on the outer chains of the glycan moieties of glycolipids or the O-linked glycans of glycoproteins, the isozymes prefer sialylated, alphaFucT III, V, VI, and VII, or nonsialylated, alphaFucT IV and IX, N-acetyllactosamine	Homo sapiens	GDP + fucosylated Lewis antigen	-	?

Synonyms

Synonyms	Comment	Organism
alpha1,3 fucosyltransferase	-	Homo sapiens
alpha1,3/1,4FucT III	-	Homo sapiens
alpha1,3FucT IV	-	Homo sapiens
alpha1,3FucT IX	-	Homo sapiens
alpha1,3FucT V	-	Homo sapiens
alpha1,3FucT VI	-	Homo sapiens
alpha1,3FucT VII	-	Homo sapiens
alphaFucT	-	Homo sapiens

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Release 2023.1 (January 2023)