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Literature summary for 2.4.1.65 extracted from

  • Rasko, D.A.; Wang, G.; Palcic, M.M.; Taylor, D.E.
    Cloning and characterization of the alpha(1,3/4) fucosyltransferase of Helicobacter pylori (2000), J. Biol. Chem., 275, 4988-4994.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
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 Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R Helicobacter pylori inactivation of the enzyme eliminates expression of all Lewis antigens GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R Helicobacter pylori UA948 inactivation of the enzyme eliminates expression of all Lewis antigens GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori O32631
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-
Helicobacter pylori UA948 O32631
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R the enzyme appears to add fucose with a greater than 5fold preference for type II chains but still retains significant activity using type I acceptors. The addition of fucose to type II acceptors does not appear to be affected by fucosylation at other sites on the carbohydrate acceptor Helicobacter pylori GDP + 1,3-beta-D-galactosyl-(alpha-1,4-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R the enzyme appears to add fucose with a greater than 5fold preference for type II chains but still retains significant activity using type I acceptors. The addition of fucose to type II acceptors does not appear to be affected by fucosylation at other sites on the carbohydrate acceptor Helicobacter pylori UA948 GDP + 1,3-beta-D-galactosyl-(alpha-1,4-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R inactivation of the enzyme eliminates expression of all Lewis antigens Helicobacter pylori GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?
GDP-L-fucose + 1,3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R inactivation of the enzyme eliminates expression of all Lewis antigens Helicobacter pylori UA948 GDP + 1,3-beta-D-galactosyl-(alpha-(1,4)-L-fucosyl)-N-acetyl-D-glucosaminyl-R
-
 ?