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Literature summary for 2.4.1.62 extracted from

  • Yip, M.C.M.; Dain, J.A.
    Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase (1970), Biochem. J., 118, 247-252.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.62

Inhibitors

Inhibitors Comment Organism Structure
Gangliosides and ganglioside components most active: disialoganglioside Lithobates pipiens
GM2 above 1.83 mM Lithobates pipiens
additional information no inhibition by fetuin, glucosylceramide, lactosylceramide or trihexosylceramide Lithobates pipiens
N-acetylneuraminic acid with or without tetrahexosylceramide Lithobates pipiens
N-acetylneuraminyllactose weak Lithobates pipiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
-
 Lithobates pipiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Lithobates pipiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ requirement, Km-value: 2.2 mM Lithobates pipiens
additional information no activation Co2+, Na+, Li+ Lithobates pipiens
additional information no activation by K+, Al3+ Lithobates pipiens

Organism

Organism UniProt Comment Textmining
Lithobates pipiens
-
 frog
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Lithobates pipiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine best acceptor Lithobates pipiens UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.3 adult frog brain Lithobates pipiens