Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.50 extracted from

  • Webster, J.A.; Yang, Z.; Kim, Y.H.; Loo, D.; Mosa, R.M.; Li, H.; Chen, C.
    Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation (2017), Biosci. Rep., 37, BSR20170105 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NBJ5
-
-
Mus musculus Q8K297
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
COLGALT1
-
Mus musculus

General Information

General Information Comment Organism
physiological function knockdown of GLT25D1 HEK cells modified for the stable expression of adiponectin (Adipo-HEK cell) as well as in Simpson Golabi-Behmel-Syndrome adipocytes (SGBS) causes a significant decrease in high-molecular-weight adiponectin in Adipo-HEK cells with no change in total adiponectin. Knockdown in the SGBS cells caused an increase in lipid accumulation yet inhibits adipogenesis. Adiponectin forms a protein complex with lysyl hydroxylase 3 and GLT25D1. The intracellular retention of lysyl hydroxylase 3 is dependent on GLT25D1 Homo sapiens
physiological function mice fed a standard chow or high-fat diet for 5 weeks show significantly decreased level of GLT25D1 which coincides with a decrease in high-molecular-weight adiponectin Mus musculus