Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NBJ5 | - |
- |
Mus musculus | Q8K297 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
COLGALT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of GLT25D1 HEK cells modified for the stable expression of adiponectin (Adipo-HEK cell) as well as in Simpson Golabi-Behmel-Syndrome adipocytes (SGBS) causes a significant decrease in high-molecular-weight adiponectin in Adipo-HEK cells with no change in total adiponectin. Knockdown in the SGBS cells caused an increase in lipid accumulation yet inhibits adipogenesis. Adiponectin forms a protein complex with lysyl hydroxylase 3 and GLT25D1. The intracellular retention of lysyl hydroxylase 3 is dependent on GLT25D1 | Homo sapiens |
physiological function | mice fed a standard chow or high-fat diet for 5 weeks show significantly decreased level of GLT25D1 which coincides with a decrease in high-molecular-weight adiponectin | Mus musculus |