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Literature summary for 2.4.1.5 extracted from

  • Rather, S.A.; Sharma, S.C.; Mahmood, A.
    pH dependent effects of sodium ions on dextransucrase activity in Streptococcus mutans (2019), Biochem. Biophys. Rep., 20, 100692 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.5

Application

Application Comment Organism
medicine the effects of sodium ions on dextran succrase activity are specific, thus it can be useful to block its catalytic activity, and reducing the cariogenic potential of Streptococcus mutans Streptococcus mutans

Inhibitors

Inhibitors Comment Organism Structure
NaCl only the hydrolytic activity of the dextransuccrase is influenced by sodium ions, whereas there is no effect on glucosyltransferase activity. 0.5 mM, 65% inhibition of hydrolytic activity, 20 mM, 90% inhibition of hydrolytic activity. The enzyme shows biphasic effects in response to Na+ ions. The enzyme activity is restored by 86% after dialysis compared to the control enzyme preparation. No effect on in presence of other monovalent cations (Rb+, Cs+, and K+). The effects of sodium ions on dextransuccrase activity are specific, thus it can be useful to block its catalytic activity, and reducing the cariogenic potential of Streptococcus mutans Streptococcus mutans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
21.36
-
 sucrose pH 6.8, 37°C Streptococcus mutans
71.92
-
 sucrose pH 5.2, 37°C Streptococcus mutans
285.22
-
 sucrose pH 8.0, 37°C Streptococcus mutans

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-
Streptococcus mutans MTCC 890
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sucrose + dextran dextransucrase exhibits both hydrolytic and transferase activities. It catalyses the transfer of glucosyl residues from sucrose to dextran to form complex polysaccharides Streptococcus mutans ?
-
 ?
sucrose + dextran dextransucrase exhibits both hydrolytic and transferase activities. It catalyses the transfer of glucosyl residues from sucrose to dextran to form complex polysaccharides Streptococcus mutans MTCC 890 ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Streptococcus mutans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
 Streptococcus mutans

General Information

General Information Comment Organism
metabolism key enzyme in Streptococcus mutans for the metabolism of sucrose which helps in the adherence and accumulation of bacteria on tooth surface leading to the formation of dental caries Streptococcus mutans