Literature summary for 2.4.1.5 extracted from

Lee, C.G.; Park, J.K.
Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans (2015), Appl. Microbiol. Biotechnol., 99, 7495-7503.

Search for more literature for 2.4.1.5

Activating Compound

Activating Compound	Comment	Organism	Structure
alginate	80% activation	Streptococcus mutans
D-galactose	30% activation at 1%, with concentration of 1% sucrose	Streptococcus mutans
D-mannose	40% activation at 1%, with concentration of 1% sucrose	Streptococcus mutans
fucoidan	20% activation	Streptococcus mutans
lactose	50% activation at 1%, with concentration of 1% sucrose	Streptococcus mutans
additional information	water-soluble extract of Artemisia annua , 2.5fold enzyme activation	Streptococcus mutans
additional information	water-soluble extract of Artemisia sajaval , 3fold enzyme activation	Streptococcus mutans

Inhibitors

Inhibitors	Comment	Organism	Structure
beta-Glucan	slight inhibition	Streptococcus mutans
chitosan	various sizes of chitosans (CTSN, CTSN-P, CTSN-B, and CTSN-S) prepared as low molecular weight chitosan show significant inhibitory effect on enzyme DSase activity, antimicrobial activity of CTSNs toward Streptococcus mutans, overview	Streptococcus mutans
D-galactosamine	complete inhibition at 1% versus 1% sucrose	Streptococcus mutans
D-glucosamine	complete inhibition at 1% versus 1% sucrose	Streptococcus mutans
D-mannosamine	complete inhibition at 1% versus 1% sucrose	Streptococcus mutans
D-xylose	about 40% inhibition at 1% versus 1% sucrose	Streptococcus mutans
hyaluronic acid	molecular weight of about 8.9 kDa	Streptococcus mutans
additional information	D-glucose has no effect on enzyme ativity; water-soluble extract of Curcuma sp., strong enzyme inhibition	Streptococcus mutans
sulfated chitin	-	Streptococcus mutans

Organism

Organism	UniProt	Comment	Textmining
Streptococcus mutans	-	-	-
Streptococcus mutans ATCC 700610 / UA159	-	-	-

Synonyms

Synonyms	Comment	Organism
DSase	-	Streptococcus mutans

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.5	7	assay at	Streptococcus mutans

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Release 2023.1 (January 2023)