Literature summary for 2.4.1.47 extracted from

Pannuzzo, G.; Graziano, A.C.; Pannuzzo, M.; Masman, M.F.; Avola, R.; Cardile, V.
Zoledronate derivatives as potential inhibitors of uridine diphosphate-galactose ceramide galactosyltransferase 8 A combined molecular docking and dynamic study (2016), J. Neurosci. Res., 94, 1318-1326 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular modeling of structure and docking of UDP-Gal, inhibitor zoledronate and inhibitor derivatives. substrate UDP-Gal interacts with amino acids A295, G296, R322, Q343, H358, N362, S363, F380, H383	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
zoledronate	optimal inhibitor of human ceramide galactosyltransferase, showing a favorable steric hindrance factor in contrast to other inhibitors or UDP-gal. It exhibits binding sites distributed homogeneously that can bind simultaneously	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16880	-	-

Synonyms

Synonyms	Comment	Organism
UGT8	-	Homo sapiens

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Release 2023.1 (January 2023)