Literature summary for 2.4.1.46 extracted from

Nitenberg, M.; Makshakova, O.; Rocha, J.; Perez, S.; Marechal, E.; Block, M.A.; Girard-Egrot, A.; Breton, C.
Mechanism of activation of plant monogalactosyldiacylglycerol synthase 1 (MGD1) by phosphatidylglycerol (2020), Glycobiology, 30, 396-406 .

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Protein Variants

Protein Variants	Comment	Organism
H115A	residue H115 is involved in phosphatidylglycerol binding. Mutant is totally inactive in the presence or absence of anionic lipids	Arabidopsis thaliana
P189A	residue P189 is involved in phosphatidylglycerol binding. Mutant is inactive in the presence of phosphatidylglycerol and retains significant activity in the presence of phosphatidic acid	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
chloroplast	-	Arabidopsis thaliana	9507	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	O81770	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	reaction is proposed to to occur in a single displacement SN2 mechanism, with formation of an oxocarbenium ion transition state assisted by a catalytic base, H155. Phosphatidylglycerol binds to the active site where it is stabilized by interactions involving residues P189 and H155, creating an acid-base charge-relay system	Arabidopsis thaliana	?	-	-

Synonyms

Synonyms	Comment	Organism
MGD1	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
physiological function	MGD1 induces a reorganization of lipids by attracting diacylglycerol molecules to create an optimal platform for binding	Arabidopsis thaliana

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Release 2023.1 (January 2023)