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Literature summary for 2.4.1.41 extracted from
- Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome (2020), J. Biol. Chem., 295, 1411-1425 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | isoform Galnt3-deficient mice serve as a model for the disease hyperphosphatemic familial tumoral calcinosis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P70419 | isoform Galnt3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| salivary gland | Galnt3 is the major O-glycosyltransferase expressed in the secretory cells of salivary glands | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc10 | - |
Mus musculus | UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc10 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GALNT3 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | loss of Galnt3 results in changes in the structure, composition, and stability of the oral microbiome. The major secreted salivary mucin, Muc10, is an in vivo substrate of Galnt3 | Mus musculus |
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