Literature summary for 2.4.1.41 extracted from

Hintze, J.; Ye, Z.; Narimatsu, Y.; Madsen, T.D.; Joshi, H.J.; Goth, C.K.; Linstedt, A.; Bachert, C.; Mandel, U.; Bennett, E.P.; Vakhrushev, S.Y.; Schjoldager, K.T.
Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines (2018), J. Biol. Chem., 293, 19064-19077 .

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Application

Application	Comment	Organism
analysis	development of isogenic cell-model systems withTet-On inducible expression of GalNAc-T genes GALNT2 and GALNT11 in a knockout background in HEK-293 cells to identify O-glycopeptides differentially affected by induction of GalNAc-T2 or -T11	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q10471	isoform GalNAc-T2	-
Homo sapiens	Q8NCW6	isoform GalNAc-T11	-

Synonyms

Synonyms	Comment	Organism
GalNAc-T11	-	Homo sapiens
GalNAc-T2	-	Homo sapiens
GALNT11	-	Homo sapiens
GALNT2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform GalNAc-T11-specific glycosites are glycosylated in a dose-dependent manner and induction of GalNAc-T11 produces discrete glycosylation effects without affecting the major part of the O-glycoproteome. Responder proteins are the LA-2 module in VLDLR (70KTCAESDFVCNNGQCVPSR88), a glycosite just C-terminal to the single LA module in SPINT1 (328HPVCSGTCQPTQFR341), a class A repeat in LRP1 (873CDGDNDCLDNSDEAPALCHQHTCPSDR899), BCR-associated protein 29/BCAP29, cathepsin D/CTSD, neuferricin/CYB5D2, HLA-A, GRP-78/HSPA5/BiP, podocalyxin/PODXL, xyloside xylosyltransferase 1/XXYLT1, and golgin 1/GLG1	Homo sapiens
physiological function	isoform GalNAc-T2-specific glycosites are glycosylated in a dose-dependent manner and induction of GalNAc-T2 produces discrete glycosylation effects without affecting the major part of the O-glycoproteome. Responder proteins are GRP-78/HSPA5/BiP (634LYGSAGPPPTGEEDTAEKDEL654), PAPS transporter 1/SLC35B2 (137SYGATATSPGER148), 4Gal-T3/B4GALT3 (219SFPDQFSTGEPPALDEVPEVR239) (ambiguous glycosites italicized), calnexin/CANX (62APVPTGEVYFADSFDR77), GP73/GOLM1 (233SQTPAPSSEVVLDSK247 and 233SQTPAPSSE241), LRP11 (299AAYSTGGCLHTCSR312), TGN46/TGOLN2 (346MSGSASSENR355), and carboxypeptidase D/CPD (219SFPDQFSTGEPPALDEVPEVR239)	Homo sapiens

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Release 2023.1 (January 2023)