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Literature summary for 2.4.1.41 extracted from

  • Tang, J.; Zheng, H.; Chen, L.; Gao, S.; Shi, X.; Liu, J.; Xu, L.
    Isoform-specific regulation of osteogenic factors by polypeptide N-acetylgalactosaminyltransferases 1 and 4 (2017), Biochem. Biophys. Res. Commun., 482, 1449-1454 .
    View publication on PubMed
Search for more literature for 2.4.1.41

Organism

Organism UniProt Comment Textmining
Mus musculus O08832 isoform GALNT4
-
Mus musculus O08912 isoform GALNT1
-

Source Tissue

Source Tissue Comment Organism Textmining
MC3T3-E1 cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
GALNT1
-
 Mus musculus
Galnt4
-
 Mus musculus

General Information

General Information Comment Organism
physiological function both GalNAc-T1 and -T4 isoforms are highly expressed during osteogenesis of MC3T3-E1 pre-osteoblasts and their knockdown by short hairpin RNA decreases osteoblast formation and bone mineralization. Knockdown of GalNAc-T1 or -T4 decreases mRNA and protein levels of bone sialoprotein. Knockdown of GalNAc-T1 decreases mRNA levels of osteocalcin and osteoprotegerin. Knockdown of T1 or T4 isoforms does not change the expression of osteopontin, COLLI, receptor activator for nuclear factor-kappaB ligand and transforming growth factor-beta Mus musculus
physiological function both GalNAc-T1 and -T4 isoforms are highly expressed during osteogenesis of MC3T3-E1 pre-osteoblasts and their knockdown by short hairpin RNA decreases osteoblast formation and bone mineralization. Knockdown of GalNAc-T1 or -T4 decreases mRNA and protein levels of bone sialoprotein. Knockdown of GalNAc-T4 decreases mRNA levels osteocalcin, osteoprotegerin and vitamin D receptor. Knockdown of T1 or T4 isoforms does not change the expression of osteopontin, COLLI, receptor activator for nuclear factor-kappaB ligand and transforming growth factor-beta Mus musculus