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Literature summary for 2.4.1.41 extracted from

  • Voglmeir, J.; Laurent, N.; Flitsch, S.L.; Oelgeschlaeger, M.; Wilson, I.B.
    Biological and biochemical properties of two Xenopus laevis N-acetylgalactosaminyltransferases with contrasting roles in embryogenesis (2015), Comp. Biochem. Physiol. B, 180, 40-47.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.41

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris strain GS115 Xenopus laevis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates activity to a lesser extent than Mn2+ or Co2+ Xenopus laevis
Co2+ isoform GalNAcT-16 prefers Co2+ over Mn2+ Xenopus laevis
Fe2+ stimulates activity to a lesser extent than Mn2+ or Co2+ Xenopus laevis
Mg2+ stimulates activity to a lesser extent than Mn2+ or Co2+ Xenopus laevis
Mn2+ isoform GalNAcT-6 prefers Mn2+ over Co2+ Xenopus laevis
Ni2+ stimulates activity to a lesser extent than Mn2+ or Co2+ Xenopus laevis
Zn2+ stimulates activity to a lesser extent than Mn2+ or Co2+ Xenopus laevis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 x * 60000, isoform GalNac-T16, SDS-PAGE Xenopus laevis
75000
-
 x * 75000, isoform GalNac-T6, SDS-PAGE Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein isoform GlaNac-T6 contains two potential N-glycosylation sites Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + neuroglycan
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-neuroglycan
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide ActR-IIB
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide ActR-IIB
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr1
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr1
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr2
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr2
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr3
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr3
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc5Ac
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc5Ac
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS1
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS1
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS4
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS4
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + polypeptide RNApII
-
 Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide RNApII
-
 ?

Subunits

Subunits Comment Organism
? x * 60000, isoform GalNac-T16, SDS-PAGE Xenopus laevis
? x * 75000, isoform GalNac-T6, SDS-PAGE Xenopus laevis

Synonyms

Synonyms Comment Organism
GalNAc-T16 isoform Xenopus laevis
GalNAc-T6 isoform Xenopus laevis
polypeptide N-acetylgalactosaminyltransferase
-
 Xenopus laevis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
42
-
-
 Xenopus laevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 below pH 6.0, the enzyme activity drops steeply, while above pH 7.0, the reduction of the activity occurs over a longer pH range Xenopus laevis