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Literature summary for 2.4.1.41 extracted from
- UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree (2012), Glycobiology, 22, 768-777.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| FLAG fusion transmembrane deletion construct expressed in COS7 cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
GT[GalNAc]TPSPVPTTST[GalNAc]TSAP | KM >2 mM | Homo sapiens |  |
| 0.035 | - |
GT[GalNAc]TPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.067 | - |
GTTPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.108 | - |
PTTDSTTPAPTTK | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.111 | - |
GTTPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.115 | - |
GTTPSPVPTTST[GalNAc]TSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.124 | - |
PTTDSTTPAPTTK | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.13 | - |
GTTPSPVPTTST[GalNAc]TSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.171 | - |
GTTPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.172 | - |
PTTDSTTPAPTTK | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.206 | - |
GT[GalNAc]TPSPVPTTST[GalNAc]TSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.263 | - |
GT[GalNAc]TPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.299 | - |
GT[GalNAc]TPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.332 | - |
GT[GalNAc]TPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.344 | - |
GTTPSPVPTTSTTSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.353 | - |
GTTPSPVPTTST[GalNAc]TSAP | pH not specified in the publication, 37°C | Homo sapiens | |
| 0.46 | - |
GTTPSPVPTTST[GalNAc]TSAP | pH not specified in the publication, 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| anti-FLAG m2 affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| spinal cord | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | most active with partially glycosylated MUC5AC (by a combination of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 and UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2) | Homo sapiens | ? | - |
? | |
| additional information | no activity observed with substrate peptides of other UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases | Homo sapiens | ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + AHGVTSAPDTR | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GAGAEAPTPAPAGAGK | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTAKPTTLKPTE | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP | - |
Homo sapiens | UDP + GT[GalNAc]TPSPVPTTSTTSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP | - |
Homo sapiens | UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP | glycosylation at Thr-3 and Thr-13 | ? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP | - |
Homo sapiens | UDP + GT[GalNAc]TP[GalNAc]SPVPTTSTTSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP | - |
Homo sapiens | UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP | - |
Homo sapiens | UDP + GT[GalNAc]TP[GalNAc]SPVPTTST[GalNAc]TSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP | - |
Homo sapiens | UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP | - |
Homo sapiens | UDP + G[GalNAc]T[GalNAc]TPSPVPTTST[GalNAc]TSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP | - |
Homo sapiens | UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + PDTRPAPGSTAPPAC | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + PSTPPTPSPSTPPTPSPS | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + PTTDSTTPAPTTK | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-N-acetyl-alpha-D-galactosamine + SPTTSTPISSTPQPTS | - |
Homo sapiens | UDP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13V1 | splice variant 1 of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13, a 198 bp intron between exons 10 and 11 is not spliced out resulting in alteration of the lectin domain | Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 17 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 19 | - |
Homo sapiens |
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20 | - |
Homo sapiens |
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