Literature summary for 2.4.1.40 extracted from

Yamamoto, M.; Tarasco, M.C.; Cid, E.; Kobayashi, H.; Yamamoto, F.
ABO blood group A transferase and its codon 69 substitution enzymes synthesize FORS1 antigen of FORS blood group system (2019), Sci. Rep., 9, 9717 .

Search for more literature for 2.4.1.40

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-1 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	preparation of human GTA derivative constructs containing any of the 20 amino acids at codon 69 with and without a GlyGlyAla substitution of the LeuGlyGly tripeptide at codons 266-268. In presence of the Forssman glycolipid synthase substrate, all substitution constructs at codon 69 exhibit Forssman glycolipid synthase activity. The combination with tripeptide GlyGlyAla substitution significantly increases the activity. With increased globoside availability, the native human GTA with a methionine residue at codon 69 also synthesizes Forssman antigen	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16442	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
physiological function	the deletion of exon 3 or 4, but not of exon 2 or 5, of human GTA transcripts bestows moderate Forssman glycolipid synthase activity. Strong Forssman glycolipid synthase activity is attained, in addition to GTA and GTB activities, by cointroducing one of those deletions and the replacement of the LeuGlyGly tripeptide sequence at codons 266 to 268 by GlyGlyAla substitution, i.e. to the residues of Forssman glycolipid synthase	Homo sapiens

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Release 2023.1 (January 2023)