Literature summary for 2.4.1.40 extracted from

Cid , E.; Yamamoto, M.; Yamamoto, F.
Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related alpha1,3 Gal(NAc) transferases with differential enzymatic activity (2019), Sci. Rep., 9, 846 .

Search for more literature for 2.4.1.40

Protein Variants

Protein Variants	Comment	Organism
additional information	amino acids at codons 266 and 268 of human isoforms GTA, EC 2.4.1.40, and GTB, EC 2.4.1.37, are crucial to their distinct sugar specificities. In vitro mutagenized GTAs/GTBs having any of 20 possible amino acids at those codons show that those codons determine the transferase activity and sugar specificity	Homo sapiens
additional information	expression of constructs, having either of AlaGlyGly, GlyGlyAla, HisAlaAla, LeuGlyGly, or MetGlyAla tripeptide sequence at codons corresponding to 266-268 of human GTA/GTB. The original human GTA construct with LeuGlyGly and the substitution construct with AlaGlyGly exhibit strong GTA. Human GTA constructs with GlyGlyAla, HisAlaAla, LeuGlyGly, or MetGlyAla exhibit GTA, GTA/GTB, GTB, GTA, or GTB activity, respectively	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16442	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)