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Literature summary for 2.4.1.386 extracted from

  • Yeh, J.; Ong, E.; Fukuda, M.
    Molecular cloning and expression of a novel beta-1,6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches (1999), J. Biol. Chem., 274, 3215-3221 .
    View publication on PubMed
Search for more literature for 2.4.1.386

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R Homo sapiens
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 UDP + beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95395 cf. ECs 2.4.1.102, 2.4.1.148 and 2.4.1.150
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Source Tissue

Source Tissue Comment Organism Textmining
colon
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 Homo sapiens
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additional information enzyme is barely expressed in testis, prostate, kidney, and pancreas Homo sapiens
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small intestine
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 Homo sapiens
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stomach
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 Homo sapiens
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thyroid gland
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 Homo sapiens
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trachea
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
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 Homo sapiens UDP + beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
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 ?

Synonyms

Synonyms Comment Organism
c2GnT-M
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 Homo sapiens
C2GnT-mucin type
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 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme plays a critical role in O-glycan synthesis in mucins, able to synthesize all known mucin beta 6 N-acetylglucosaminides. It mediates core 2 and core 4 O-glycan branching in mucin-type biosynthesis and has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans Homo sapiens