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Literature summary for 2.4.1.38 extracted from

  • Yang, H.; Yuan, Q.; Chen, Q.; Li, C.; Wu, X.; Peng, C.; Kang, L.; Lu, X.; Sun, H.; Zhou, Z.; Shen, A.; Cheng, C.
    beta-1,4-galactosyltransferase I promotes tumor necrosis factor-alpha autocrine via the activation of MAP kinase signal pathways in Schwann cells (2011), J. Mol. Neurosci., 45, 269-276.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Schwann cell
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
beta-1,4-galactosyltransferase I
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 Rattus norvegicus
beta-1,4-GalT I
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus anti-TNFR1 antibody suppresses the expression of beta-1,4-GalT I, and TNF-alpha autocrine down

General Information

General Information Comment Organism
malfunction silencing of beta-1,4-GalT I suppresses TNF-alpha autocrine, while overexpression of beta-1,4-GalT I promotes TNF-alpha autocrine in TNF-alpha-treated Schwann cells Rattus norvegicus
physiological function beta-1,4-GalT I plays a positive role in the regulation of TNF-alpha-induced TNF-alpha secretion. It promotes the activation of ERK, JNK, and P38 MAP kinase signal pathways which subsequently enhance TNF-alpha secretion in TNF-alpha-treated Schwann cells Rattus norvegicus