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Literature summary for 2.4.1.38 extracted from

  • Daligault, F.; Rahuel-Clermont, S.; Gulberti, S.; Cung, M.T.; Branlant, G.; Netter, P.; Magdalou, J.; Lattard, V.
    Thermodynamic insights into the structural basis governing the donor substrate recognition by human beta1,4-galactosyltransferase 7 (2009), Biochem. J., 418, 605-614.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells and as a fusion protein with maltose-binding protein in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by CDP, UDP-mannose, and UDP-N-acetyl-beta-D-glucosamine Homo sapiens
TDP
-
Homo sapiens
UDP
-
Homo sapiens
UTP
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
4-methylumbelliferyl beta-D-xylopyranoside purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.16
-
UDP-xylose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.23
-
UDP-galactose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.27
-
4-methylumbelliferyl beta-D-xylopyranoside purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.28
-
UDP-glucose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.31
-
UDP-galactose purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.85
-
4-nitrophenyl beta-D-xylopyranoside purified beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.27
-
4-nitrophenyl beta-D-xylopyranoside purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
4
-
UDP-glucuronic acid Km above 4 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
10
-
UDP-N-acetyl-alpha-D-glucosamine Km above 10 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
purified maltose-binding protein-beta-1,4-GalT7 protein, SDS/PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
amylose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UDP-mannose and UDP-N-acetyl galactosamine are no substrates for soluble beta1,4-GalT7 Homo sapiens ?
-
?
UDP-galactose + 4-methylumbelliferyl beta-D-xylopyranoside
-
Homo sapiens UDP + ?
-
?
UDP-galactose + 4-nitrophenyl beta-D-xylopyranoside
-
Homo sapiens UDP + beta-D-galactopyranosyl-1,4-xylopyranosyl-1-O-4-nitrophenol
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide 100% activity with UDP-galactose Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?
UDP-glucose + 4-methylumbelliferyl beta-D-xylopyranoside 1.5% activity with UDO-glucose compared to UDP-galactose Homo sapiens UDP + 4-O-beta-D-galactosyl-beta-D-glucose
-
?
UDP-glucuronic acid + 4-methylumbelliferyl beta-D-xylopyranoside
-
Homo sapiens UDP + ?
-
?
UDP-N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-xylopyranoside
-
Homo sapiens UDP + ?
-
?
UDP-N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-xylopyranoside
-
Homo sapiens ?
-
?
UDP-xylose + 4-methylumbelliferyl beta-D-xylopyranoside
-
Homo sapiens UDP + ?
-
?

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase 7
-
Homo sapiens
beta1,4-GalT7
-
Homo sapiens
galactosyltransferase 7
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.003
-
UDP-glucuronic acid Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.003
-
UDP-N-acetyl-alpha-D-glucosamine Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.01
-
UDP-xylose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.02
-
UDP-glucose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.13
-
4-methylumbelliferyl beta-D-xylopyranoside purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.14
-
UDP-galactose Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.52
-
4-nitrophenyl beta-D-xylopyranoside purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.61
-
UDP purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.65
-
UTP purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
1.93
-
TDP purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.065
-
UDP-xylose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
0.07
-
UDP-glucose purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens
4.93
-
UDP-galactose Km above 0.003 mM, purified maltose-binding protein-beta1,4-GalT7, in 100 mM cacodylate buffer (pH 7.0) containing 10 mM MnCl2, at 37°C Homo sapiens