Literature summary for 2.4.1.38 extracted from

Takaya, K.; Nagahori, N.; Kurogochi, M.; Furuike, T.; Miura, N.; Monde, K.; Lee, Y.C.; Nishimura, S.
Rational design, synthesis, and characterization of novel inhibitors for human beta1,4-galactosyltransferase (2005), J. Med. Chem., 48, 6054-6065.

Search for more literature for 2.4.1.38

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	development and synthesis of mechanism-based inhibitors, structure analysis, overview	Homo sapiens
uridine 5'-(6-amino-(2-[(7-bromomethyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate	irreversible, modifies residue Trp310	Homo sapiens
uridine 5'-(6-amino-(2-[(7-methyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate	-	Homo sapiens
uridine 5'-(6-O-[10-(2-naphthyl)-3,6,9-trioxadecanyl]-alpha-D-galactopyranosyl)diphosphate	competitive versus UDP-Gal, blocks acceptor substrate binding by the enzyme in presence of Mn2+	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00491	-	UDP-Gal	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide	Homo sapiens	-	UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide	functional role of Trp310 residue located in the small loop near the active site of the enzyme	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide	-	Homo sapiens	UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide	-	?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide	UDP-Gal-Mn2+ substrate binding structure, overview	Homo sapiens	UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide	-	?

Synonyms

Synonyms	Comment	Organism
beta1,4-galactosyltransferase	-	Homo sapiens
betaGalT-1	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00186	-	uridine 5'-(6-O-[10-(2-naphthyl)-3,6,9-trioxadecanyl]-alpha-D-galactopyranosyl)diphosphate	-	Homo sapiens
0.0223	-	uridine 5'-(6-amino-(2-[(7-methyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate	-	Homo sapiens

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Release 2023.1 (January 2023)