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Literature summary for 2.4.1.376 extracted from

  • Yu, H.; Takeuchi, H.
    Protein O-glucosylation another essential role of glucose in biology (2019), Curr. Opin. Struct. Biol., 56, 64-71 .
    View publication on PubMed
Search for more literature for 2.4.1.376

Protein Variants

Protein Variants Comment Organism
D233E the mutation causes a class of adult-onset limb-girdle muscular dystrophy with reduced Notch signaling in muscular stem cells, called satellite cells, and hypoglycosylation on alpha-dystroglycan in muscles Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose + [Notch1 protein with EGF-like domain]-L-serine Homo sapiens when glycosylating EGF repeats, the enzyme exhibits significant protein O-xylosyltransferase, preferring EGF repeats with a diserine motif in the consensus O-glucosylation motif (C1-X-S-S-(P/A)-C2) UDP + [Notch1 protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + [Notch1 protein with EGF-like domain]-L-serine when glycosylating EGF repeats, the enzyme exhibits significant protein O-xylosyltransferase, preferring EGF repeats with a diserine motif in the consensus O-glucosylation motif (C1-X-S-S-(P/A)-C2) Homo sapiens UDP + [Notch1 protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine
-
 ?

Synonyms

Synonyms Comment Organism
POGLUT1
-
 Homo sapiens
protein O-glucosyltransferase 1
-
 Homo sapiens
Rumi
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme mutations can cause Dowling-Degos disease Homo sapiens
metabolism the enzyme is necessary for efficient trafficking of endogenous Notch1 from the endoplasmic reticulum to the cell surface in HEK-293T cells Homo sapiens