Literature summary for 2.4.1.37 extracted from

Angulo, J.; Langpap, B.; Blume, A.; Biet, T.; Meyer, B.; Krishna, N.R.; Peters, H.; Palcic, M.M.; Peters, T.
Blood group B galactosyltransferase: insights into substrate binding from NMR experiments (2006), J. Am. Chem. Soc., 128, 13529-13538.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16442	recombinantly expressed in Escherichia coli	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-galactose + alpha-L-Fuc-(1,2)-beta-D-Gal-O-octyl	it is propose that, upon acceptor binding, GTB uses the Asp302 and Glu303 side chains as molecular tweezers to promote bound UDP-Gal but not UDP-Glc into a transition state that leads to product formation	Homo sapiens	UDP + alpha-L-Fuc(1,2)-[alpha-D-Galp-(1,3)-]-beta-D-Gal-O-octyl	-	?

Synonyms

Synonyms	Comment	Organism
blood group B galactosyltransferase	-	Homo sapiens
GTB	-	Homo sapiens

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Release 2023.1 (January 2023)