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Literature summary for 2.4.1.346 extracted from

  • Mishra, A.; Klein, C.; Gurcha, S.; Alderwick, L.; Babu, P.; Hitchen, P.; Morris, H.; Dell, A.; Besra, G.; Eggeling, L.
    Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant (2008), Antonie van Leeuwenhoek, 94, 277-287.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum Q8NNK8
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Corynebacterium glutamicum DSM 20300 Q8NNK8
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Synonyms

Synonyms Comment Organism
GDP-mannose-dependent monoacylated alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase
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 Corynebacterium glutamicum
NCgl2106
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 Corynebacterium glutamicum
pimB'
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 Corynebacterium glutamicum

General Information

General Information Comment Organism
physiological function disruption of gene NCgl2106 results in a mutant devoid of monoacylated phosphatidyl-myo-inositol dimannoside (Ac1PIM2) resulting in the accumulation of monoacylated phosphatidyl-myo-inositol monomannoside Ac1PIM1 and cessation of phosphatidyl-myo-inositol based lipomannan and lipoarabinomannan biosynthesis. The mutant syntheses a single novel lipoglycan possessing an alpha-D-glucopyranosyluronic acid-(1->3)-glycerol (GlcAGroAc2) based anchor which is then further glycosylated by 8–22 mannose residues, with Man12–20GlcAGroAC2 molecular species being the most abundant Corynebacterium glutamicum