Literature summary for 2.4.1.34 extracted from

Satish, S.; Jimenez-Ortigosa, C.; Zhao, Y.; Lee, M.; Dolgov, E.; Krueger, T.; Park, S.; Denning, D.; Kniemeyer, O.; Brakhage, A.; Perlin, D.
Stress-induced changes in the lipid microenvironment of beta-(1,3)-D-glucan synthase cause clinically important echinocandin resistance in Aspergillus fumigatus (2019), mBio, 10, e00779 .

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Application

Application	Comment	Organism
medicine	exposure of strain RG101 to caspofungin during growth yields a modified enzyme that is drug insensitive (4 log orders) in kinetic inhibition assays, and this insensitivity is also observed for enzymes isolated from clinical isolates. The lipid microenvironment of the enzyme with resistance induced by caspofungin reveals a prominent increase in the abundances of dihydrosphingosine and phytosphingosine. Exogenous addition of dihydrosphingosine and phytosphingosine to the sensitive enzyme recapitulates the drug insensitivity of the caspofungin-derived enzyme. Caspofungin induces mitochondrion-derived reactive oxygen species, and dampening reactive oxygen species formation by antimycin A or thiourea eliminates drug-induced resistance	Aspergillus nidulans

Inhibitors

Inhibitors	Comment	Organism	Structure
caspofungin	exposure of strain RG101 to caspofungin during growth yields a modified enzyme that is drug insensitive (4 log orders) in kinetic inhibition assays, and this insensitivity is also observed for enzymes isolated from clinical isolates. The lipid microenvironment of the enzyme with resistance induced by caspofungin reveals a prominent increase in the abundances of dihydrosphingosine and phytosphingosine. Exogenous addition of dihydrosphingosine and phytosphingosine to the sensitive enzyme recapitulates the drug insensitivity of the caspofungin-derived enzyme. Caspofungin induces mitochondrion-derived reactive oxygen species, and dampening reactive oxygen species formation by antimycin A or thiourea eliminates drug-induced resistance	Aspergillus nidulans

Organism

Organism	UniProt	Comment	Textmining
Aspergillus nidulans	-	-	-
Aspergillus nidulans RG101	-	-	-

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Release 2023.1 (January 2023)