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Literature summary for 2.4.1.34 extracted from

  • Maligie, M.A.; Selitrennikoff, C.P.
    Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins (2005), Antimicrob. Agents Chemother., 49, 2851-2856.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.34

Activating Compound

Activating Compound Comment Organism Structure
CaCl2 7 mM, 2fold increase in activity Cryptococcus neoformans
EDTA maximal activity at 50 mM Cryptococcus neoformans
MgCl2 5 mM, 3fold increase in activity Cryptococcus neoformans

Inhibitors

Inhibitors Comment Organism Structure
caspofungin 50% inhibition at 0.00013 mg/ml Aspergillus fumigatus
caspofungin 50% inhibition at 0.016 mg/ml Cryptococcus neoformans
caspofungin 50% inhibition at 0.004 mg/ml Neurospora crassa
caspofungin 50% inhibition at 0.00013 mg/ml Saccharomyces cerevisiae
cilofungin 50% inhibition at 0.064 mg/ml Cryptococcus neoformans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information optimization of in vitro assay conditions Cryptococcus neoformans
0.21
-
 UDP-glucose pH 7.75 Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-
Cryptococcus neoformans
-
-
-
Neurospora crassa
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + (1,3-beta-D-glucosyl)n
-
 Saccharomyces cerevisiae UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
UDP-glucose + (1,3-beta-D-glucosyl)n
-
 Neurospora crassa UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
UDP-glucose + (1,3-beta-D-glucosyl)n
-
 Cryptococcus neoformans UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
UDP-glucose + (1,3-beta-D-glucosyl)n
-
 Aspergillus fumigatus UDP + (1,3-beta-D-glucosyl)n+1
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.75
-
-
 Cryptococcus neoformans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00017
-
 caspofungin pH 7.75, 25°C Cryptococcus neoformans
0.00067
-
 caspofungin pH 7.75, 25°C Saccharomyces cerevisiae
0.0022
-
 caspofungin pH 7.75, 25°C Neurospora crassa
0.0041
-
 caspofungin pH 7.75, 25°C Aspergillus fumigatus
0.022
-
 cilofungin pH 7.75, 25°C Cryptococcus neoformans