Literature summary for 2.4.1.34 extracted from

Beaulieu, D.; Tang, J.; Yan, S.B.; Vessels, J.M.; Radding, J.A.; Parr, T.R., Jr.
Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase (1994), Antimicrob. Agents Chemother., 38, 937-944.

Search for more literature for 2.4.1.34

Inhibitors

Inhibitors	Comment	Organism	Structure
cilofungin	maximal inhibition at 1.25 mM is 80%; non-competitive inhibition	Aspergillus fumigatus
cilofungin	non-competitive inhibition	Candida albicans
Digitonin	-	Aspergillus fumigatus
Sarkosyl	-	Aspergillus fumigatus
Triton X-100	-	Aspergillus fumigatus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	-	-
Candida albicans	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0048	-	membrane	Aspergillus fumigatus
0.0096	-	membrane plus W-1	Aspergillus fumigatus
0.0109	-	solubilized	Aspergillus fumigatus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDPglucose + (1,3-beta-D-glucosyl)n	-	Candida albicans	UDP + (1,3-beta-D-glucosyl)n+1	-	?
UDPglucose + (1,3-beta-D-glucosyl)n	-	Aspergillus fumigatus	UDP + (1,3-beta-D-glucosyl)n+1	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)