Literature summary for 2.4.1.331 extracted from

Nybo, S.E.; Shabaan, K.A.; Kharel, M.K.; Sutardjo, H.; Salas, J.A.; Mendez, C.; Rohr, J.
Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT (2012), Bioorg. Med. Chem. Lett., 22, 2247-2250.

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Application

Application	Comment	Organism
synthesis	expression of NDP-glucose-synthase OleS, NDP-glucose-4, 6-dehydratase OleE, 2, 3-dehydratase OleV, 3, 5-epimerase OleL and 3-ketoreductase OleW in combination with elloramycin glycosyltransferase ElmGt in Streptomyces lividans results in accumulation of 8-demthyltetracenomycin C plus 8-demethyl-8-(4-dehydro)-alpha-L-olivosyl-tetracenomycin and 8-demethyl-8-alpha-L-olivosyl-tetracenomycin	Streptomyces olivaceus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Streptomyces lividans TK 24	Streptomyces olivaceus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces olivaceus	Q9F2F9	-	-
Streptomyces olivaceus Tü2353	Q9F2F9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C	-	Streptomyces olivaceus	dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C	-	?
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C	-	Streptomyces olivaceus Tü2353	dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C	-	?
NDP-4-dehydro-L-olivose + 8-demethyltetracenomycin C	-	Streptomyces olivaceus	NDP + 8-demethyl-8-alpha-(4-dehydro-L-olivosyl)tetracenomycin C	-	?
NDP-4-dehydro-L-olivose + 8-demethyltetracenomycin C	-	Streptomyces olivaceus Tü2353	NDP + 8-demethyl-8-alpha-(4-dehydro-L-olivosyl)tetracenomycin C	-	?

Synonyms

Synonyms	Comment	Organism
elloramycin glycosyltransferase	-	Streptomyces olivaceus
ElmGT	-	Streptomyces olivaceus

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Release 2023.1 (January 2023)