Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.331 extracted from

  • Nybo, S.E.; Shabaan, K.A.; Kharel, M.K.; Sutardjo, H.; Salas, J.A.; Mendez, C.; Rohr, J.
    Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT (2012), Bioorg. Med. Chem. Lett., 22, 2247-2250.
    View publication on PubMed
Search for more literature for 2.4.1.331

Application

Application Comment Organism
synthesis expression of NDP-glucose-synthase OleS, NDP-glucose-4, 6-dehydratase OleE, 2, 3-dehydratase OleV, 3, 5-epimerase OleL and 3-ketoreductase OleW in combination with elloramycin glycosyltransferase ElmGt in Streptomyces lividans results in accumulation of 8-demthyltetracenomycin C plus 8-demethyl-8-(4-dehydro)-alpha-L-olivosyl-tetracenomycin and 8-demethyl-8-alpha-L-olivosyl-tetracenomycin Streptomyces olivaceus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Streptomyces lividans TK 24 Streptomyces olivaceus

Organism

Organism UniProt Comment Textmining
Streptomyces olivaceus Q9F2F9
-
-
Streptomyces olivaceus Tü2353 Q9F2F9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
-
 ?
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus Tü2353 dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
-
 ?
NDP-4-dehydro-L-olivose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus NDP + 8-demethyl-8-alpha-(4-dehydro-L-olivosyl)tetracenomycin C
-
 ?
NDP-4-dehydro-L-olivose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus Tü2353 NDP + 8-demethyl-8-alpha-(4-dehydro-L-olivosyl)tetracenomycin C
-
 ?

Synonyms

Synonyms Comment Organism
elloramycin glycosyltransferase
-
 Streptomyces olivaceus
ElmGT
-
 Streptomyces olivaceus