Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | Homo sapiens | - |
UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the enzyme is N-glycosylated on both Asn-116 and Asn-174. This modification is necessary for its secretion in breast cancer cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | - |
Homo sapiens | UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
B3GALNT2 | - |
Homo sapiens |
beta1,3-N-acetylgalactosaminyltransferase II | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression is exclusively upregulated in the majority of breast cancers | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of B3GALNT2 expression attenuates cell growth and induced apoptosis in breast cancer cells | Homo sapiens |