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Literature summary for 2.4.1.312 extracted from

  • Ogawa, M.; Nakamura, N.; Nakayama, Y.; Kurosaka, A.; Manya, H.; Kanagawa, M.; Endo, T.; Furukawa, K.; Okajima, T.
    GTDC2 modifies O-mannosylated ?-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody (2013), Biochem. Biophys. Res. Commun., 440, 88-93.
    View publication on PubMed
Search for more literature for 2.4.1.312

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan in the endoplasmic reticulum ?
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] Homo sapiens
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 UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan in the endoplasmic reticulum Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein]
-
 Homo sapiens UDP + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
-
 ?

Synonyms

Synonyms Comment Organism
GTDC2 gene name, glycosyltransferase-like domain containing 2 Homo sapiens
O-mannose beta-1,4-N-acetylglucosaminyltransferase
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 Homo sapiens
POMGNT2
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 Homo sapiens

General Information

General Information Comment Organism
malfunction mutations of GTDC2 are identified in Walker-Warburg syndrome Homo sapiens