Literature summary for 2.4.1.288 extracted from

Li, J.; Lowary, T.
Sulfonium ions as inhibitors of the mycobacterial galactofuranosyltransferase GlfT2 (2014), MedChemComm, 5, 1130-1137.

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3S,4S)-3-(1,2-dihydroxyethyl)-4-hydroxy-1-(2-phenylethyl)tetrahydrothiophenium chloride	sulfonium ion compound as analogue of the donor substrate, uridine diphosphategalactofuranose. The compound contains moieties that mimic both galactofuranose and uridine diphosphate domains, and carries a permanent positive charge to mimic the oxocarbenium ion-like transition state. About 60% inhibition at 4 mM	Mycobacterium tuberculosis
(3S,4S)-3-(1,2-dihydroxyethyl)-4-hydroxy-1-[2-(4-nitrophenyl)ethyl]tetrahydrothiophenium bromide	sulfonium ion compound as analogue of the donor substrate, uridine diphosphategalactofuranose. The compound contains moieties that mimic both galactofuranose and uridine diphosphate domains, and carries a permanent positive charge to mimic the oxocarbenium ion-like transition state. About 50% inhibition at 4 mM	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	O53585	-	-
Mycobacterium tuberculosis ATCC 25618	O53585	-	-

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Release 2023.1 (January 2023)