Literature summary for 2.4.1.277 extracted from

Shinde, P.B.; Han, A.R.; Cho, J.; Lee, S.R.; Ban, Y.H.; Yoo, Y.J.; Kim, E.J.; Kim, E.; Song, M.C.; Park, J.W.; Lee, D.G.; Yoon, Y.J.
Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17 (2013), J. Biotechnol., 168, 142-148.

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Application

Application	Comment	Organism
synthesis	expression of different deoxysugar biosynthetic gene cassettes and the gene encoding a substrate-flexible glycosyltransferase DesVII in Streptomyces venezuelae YJ003 mutant strain bearing a deletion of a desosamine biosynthetic (des) gene cluster. The resulting recombinants produce macrolide antibiotic YC-17 analogs possessing unnatural sugars replacing native D-desosamine. These metabolites are D-quinovosyl-10-deoxymethynolide, L-rhamnosyl-10-deoxymethynolide, L-olivosyl-10-deoxymethynolide, and D-boivinosyl-10-deoxymethynolide	Streptomyces venezuelae

Organism

Organism	UniProt	Comment	Textmining
Streptomyces venezuelae	Q9ZGH7	-	-
Streptomyces venezuelae ATCC 15439	Q9ZGH7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide	-	Streptomyces venezuelae	dTDP + 10-deoxymethymycin	-	?
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide	-	Streptomyces venezuelae ATCC 15439	dTDP + 10-deoxymethymycin	-	?
dTDP-D-boivinose + 10-deoxymethynolide	-	Streptomyces venezuelae	dTDP + D-boivinosyl-10-deoxymethynolide	-	?
dTDP-D-boivinose + 10-deoxymethynolide	-	Streptomyces venezuelae ATCC 15439	dTDP + D-boivinosyl-10-deoxymethynolide	-	?
dTDP-D-quinovose + 10-deoxymethynolide	-	Streptomyces venezuelae	dTDP + D-quinovosyl-10-deoxymethynolide	-	?
dTDP-D-quinovose + 10-deoxymethynolide	-	Streptomyces venezuelae ATCC 15439	dTDP + D-quinovosyl-10-deoxymethynolide	-	?
dTDP-L-olivose + 10-deoxymethynolide	-	Streptomyces venezuelae	dTDP + L-olivosyl-10-deoxymethynolide	-	?
dTDP-L-olivose + 10-deoxymethynolide	-	Streptomyces venezuelae ATCC 15439	dTDP + L-olivosyl-10-deoxymethynolide	-	?
dTDP-L-rhamnose + 10-deoxymethynolide	-	Streptomyces venezuelae	dTDP + L-rhamnosyl-10-deoxymethynolide	substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin	?
dTDP-L-rhamnose + 10-deoxymethynolide	-	Streptomyces venezuelae ATCC 15439	dTDP + L-rhamnosyl-10-deoxymethynolide	substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin	?

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Release 2023.1 (January 2023)